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A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide), a member of a subfamily of insect FMRFamide-related peptides.

机译：昆虫FMRFamide相关肽亚家族成员ShistoFLRFamide（PDVDHVFLRFamide）的无脊椎动物受体的非肽激动剂。

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We describe a nonpeptide mimetic analog of an invertebrate peptide receptor. Benzethonium chloride (Bztc) is an agonist of the SchistoFLRFamide (PDVDHVFLRFamide) receptors found on locust oviducts. Bztc competitively displaces [125I-labeled Y1]SchistoFLRFamide binding to both high- and low-affinity receptors of membrane preparations. Bztc mimics the physiological effects of SchistoFLRFamide on locust oviduct, by inhibiting myogenic and induced contractions in a dose-dependent manner. Bztc is therefore recognized by the binding and activation regions of the SchistoFLRFamide receptors. This discovery provides a unique opportunity within insects to finally target a peptide receptor for the development of future pest management strategies.

机译：我们描述了无脊椎动物肽受体的非肽模拟物。苄索氯铵（Bztc）是在蝗虫输卵管上发现的SchistoFLRFamide（PDVDHVFLRFamide）受体的激动剂。 Bztc竞争性地取代[125I标记的Y1] SchistoFLRFamide与膜制品的高亲和力和低亲和力受体结合。 Bztc通过以剂量依赖性方式抑制肌原性和诱导性收缩，从而模拟了SchistoFLRFamide对蝗虫输卵管的生理作用。因此，Bztc被血吸虫FLRFamide受体的结合和激活区域识别。这一发现为昆虫内部最终靶向肽受体提供了独特的机会，以开发未来的害虫管理策略。

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Lange, A B; Orchard, I; Wang, Z; Nachman, R J;
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年度 1995
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1. A NONPEPTIDE AGONIST OF THE INVERTEBRATE RECEPTOR FOR SCHISTOFLRFAMIDE (PDVDHVFLRFAMIDE), A MEMBER OF A SUBFAMILY OF INSECT FMRFAMIDE-RELATED PEPTIDES [J] . Lange AB., Wang ZX., Nachman RJ., Proceedings of the National Academy of Sciences of the United States of America . 1995,第20期

机译：血吸虫酰胺（PDVDHVFLRFAMIDE）无脊椎动物受体的非肽激动剂，是与乙酰胺相关的肽家族的成员
2. Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors [J] . MorenoP., ManteyS.A., Nuche-BerenguerB., The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2013,第1期

机译：轰击蛋白受体亚型3，非肽激动剂MK-5046，通用肽激动剂和人轰击蛋白受体的肽拮抗剂Bantag-1的比较药理学
3. First Reported Nonpeptide AT_1 Receptor Agonist (L-162,313) Acts as an AT_2 Receptor Agonist in Vivo [J] . Yiqian Wan, Charlotta Wallinder, Berndt Johansson, Journal of Medicinal Chemistry . 2004,第6期

机译：首次报道的非肽AT_1受体激动剂（L-162,313）在体内充当AT_2受体激动剂
4. Selective GLP-1 receptor antagonists and glucagon/GLP-1 co-agonists discovered through an investigation into the structure-activity relationship in glucagon-related peptides. [D] . Patterson, James T. 2011

机译：通过研究胰高血糖素相关肽的结构-活性关系，发现了选择性的GLP-1受体拮抗剂和胰高血糖素/ GLP-1共激动剂。
5. A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide) a member of a subfamily of insect FMRFamide-related peptides. [O] . A B Lange, I Orchard, Z Wang, 1995

机译：昆虫FMRFamide相关肽亚家族成员ShistoFLRFamide（PDVDHVFLRFamide）的无脊椎动物受体的非肽激动剂。
6. Comparative Pharmacology of Bombesin Receptor Subtype-3, Nonpeptide Agonist MK-5046, a Universal Peptide Agonist, and Peptide Antagonist Bantag-1 for Human Bombesin Receptors [O] . Paola Moreno, Samuel A. Mantey, Bernardo Nuche-Berenguer, 2013

机译：Bombesin受体亚型-3，非肽激动剂MK-5046，一种通用肽激动剂和肽拮抗剂Bantag-1用于人Bombesin受体的对比药理学

A nonpeptide agonist of the invertebrate receptor for SchistoFLRFamide (PDVDHVFLRFamide), a member of a subfamily of insect FMRFamide-related peptides.

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